Home Chemistry Heterocyclic Building Blocks Aliphatic Heterocycles (1R,5S)-3-Azabicyclo[3.1.0]Hexane
Nucleophilic Substitution Reactions: The amine group in norbornane amine can act as a nucleophile, participating in substitution reactions with electrophiles. For example, it can react with alkyl halides to form N-alkylated products.
Reductive Amination: (1R,5S)-3-azabicyclo[3.1.0]hexane can undergo reductive amination reactions when reacted with aldehydes or ketones in the presence of reducing agents like sodium borohydride. This can lead to the formation of N-alkylated or N-acylated products.
Acylation: It can react with acylating agents (e.g., acyl chlorides) to form N-acylated derivatives.
Ring-Opening Reactions: The bridged structure of norbornane amine can undergo ring-opening reactions under certain conditions, such as exposure to strong acids or heat. This can lead to the formation of open-chain amines.
Cycloaddition Reactions: Depending on the reaction conditions and reagents, (1R,5S)-3-azabicyclo[3.1.0]hexane can participate in cycloaddition reactions, such as Diels-Alder reactions, which can lead to the formation of more complex cyclic compounds.
Oxidation: The amine group can be oxidized to form an N-oxide or other oxidation products when exposed to strong oxidizing agents.
Reduction: The bicyclic structure can be reduced using reducing agents to form saturated derivatives.
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(1S,2S,5R)-rel-3-Azabicyclo[3.1.0]hexan-2-ylmethanol hydrochloride
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rel-(1R,5S,6r)-tert-Butyl 6-formyl-3-azabicyclo[3.1.0]hexane-3-carboxylate
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rel-(1R,5S,6r)-tert-Butyl 6-(hydroxymethyl)-3-azabicyclo[3.1.0]hexane-3-carboxylate
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cis-tert-Butyl 6-acetyl-3-azabicyclo[3.1.0]hexane-3-carboxylate
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rel-(1R,5S,6r)-3-(tert-Butoxycarbonyl)-3-azabicyclo[3.1.0]hexane-6-carboxylic acid
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rel-(1R,5S,6s)-tert-Butyl 6-amino-3-azabicyclo[3.1.0]hexane-3-carboxylate
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Endo-6-Amino-3-boc-3-azabicyclo[3.1.0]hexane
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(1R,2S,5S)-6,6-Dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid hydrochloride
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(1R,2S,5S)-3-(tert-Butoxycarbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid
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(1R,2S,5S)-rel-3-(tert-Butoxycarbonyl)-6,6-dimethyl-3-azabicyclo[3.1.0]hexane-2-carboxylic acid
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